The initiative has a total budget of \u20ac2,032,281 and has been approved by the Government of Navarre, supported by a grant co-funded at 40% by the European Regional Development Fund (ERDF) under Navarre\u2019s ERDF Operational Programme 2021\u20132027.<\/p>\n
Enzybiotic-based therapeutic innovation<\/strong><\/p>\n Enzineto-V is developing an innovative solution based on enzybiotics\u2014proteins engineered to identify and destroy resistant bacteria with high precision. This approach makes it possible to target only the pathogens responsible for the infection, preserving beneficial microbiota and opening up new therapeutic pathways for severe infections in hospital settings.<\/p>\n The project aims to develop and validate preclinically a new enzybiotic targeting Acinetobacter baumannii, a pathogen strongly associated with infections in intensive care units and increasingly resistant to conventional antibiotic treatments.<\/p>\n In addition, two routes of administration tailored to patients\u2019 clinical profiles will be explored: intravenous, aimed at critically ill patients who are intubated in ICU; and intranasal, designed for chronic non-intubated patients.<\/p>\n